Foto: A. Schroll

Area of Research

Biomaterials

Foto: A. Schroll

Area of Research

Biomaterials

Foto: A. Schroll

Area of Research

Biomaterials

Foto: A. Schroll

Area of Research

Biomaterials

Synthesis Services of the Department of Biomaterials

For the scale-up of a synthesis developed in the laboratory, process steps have to be optimized. Sometimes they have to be redesigned and adapted to technical conditions. Often, the individual production of sample specimens in quantities of several hundred grams up to several kilograms is required for further investigations. In order to be able to meet these requirements of industrial partners and companies, we at INNOVENT have set up the SYNPROLAB pilot laboratory for scale-up, process optimization and adaptation.

As a highly competent partner, we offer the synthesis and modification of biopolymers and biocompatible synthetic polymers. We will be pleased to answer your concrete synthesis requests and will also respond to individual preferences regarding quantity, special specifications or analytical characterization methods.

Below you will find an overview of our synthesis services. We look forward to your inquiry, by phone or e-mail. 

 

Functionalized Chitosans
Ref-N°SubstanceMolar mass (kDa)Degree of functionalisationBatch size 

BMA-
S-001

neutrally soluble
chitosan

various high and low viscosity chitosans (educt)

DD in the range of 40 - 60 %

1 - 10 g

 

BMA-S-002

N-carboxymethyl-chitosan

various high and low viscosity chitosans (educt)

about 90 % of the free  NH2 groups are carboxymethylated

1 - 5 g

 

BMA-S-003

chitosan, quaternized (with alkyl iodide)

various high and low viscosity chitosans (educt)

variable

1 - 10 g

 

BMA-S-004

methacrylated chitosan derivatives

various high and low viscosity chitosans (educt)

DS < 1

1 - 10 g

 

DS = average degree of substitution
DD = degree of deacetylation
 

Further information on functionalized chitosans and polysaccharide derivatives can be found here.

Functionalized Dextranes
Ref-N°SubstanceMolar mass (kDa)Degree of functionalisationBatch size 

BMA-S-005

carboxymethyl dextran

20, 100 or 500 (edukt)

simple CM: DS approx. 0,6 - 0,8

double CM: DS approx. 0,9 - 1,1

triple CM: DS approx. 1,2 - 1,4

1 - 20 g

Datasheet

BMA-S-006

carboxyethyl dextran

20, 100 or 500  (edukt)

DS ≤ 1

1 - 10 g

Datasheet

BMA-S-007

amino dextran

20, 100 or 500 (edukt)

NH2-content: variable, 80 - 350 µmol/g

1 - 20 g

Datasheet

BMA-S-008

methacrylated dextran20, 100 or 500 (edukt)DS < 1

1 - 10 g

Datasheet

BMA-S-009

methacrylated amino dextran20, 100 or 500 (edukt)

DS (M) < 1

NH2-content: 10 - 50 µmol/g

1 - 10 g

Datasheet

BMA-S-010

methacrylated carboxyethyl dextran20, 100 or 500 (edukt)

DS (CE) ≤ 1

DS (M) < 1

1 - 10 g

Datasheet

BMA-S-011

amino carboxyethyl dextran20, 100 or 500 (edukt)

DS (CE) ≤ 1

NH2-content: variable, 100 - 1200 µmol/g

1 - 10 g

Datasheet

BMA-S-012

fluorescein-labeled aminodextran20, 100 or 500 (edukt)

DS (F) < 1

NH2-content: variable, 20 - 250 µmol/g

1 - 20 g

Datasheet

DS = average degree of substitution

Further information on functionalized dextran and polysaccharide derivatives can be found here.

Functionalized Levans
Ref-N°SubstanceMolar mass (kDa)Degree of functionalisationBatch size 

BMA-S-013

methacrylated levan (ether/ester)

600 - 1000 (edukt)

DS < 1

1 - 10 g

Datasheet

BMA-S-014

methacrylated levan (urethan)

600 - 1000 (edukt)

DS < 1

1 - 10 g

Datasheet

BMA-S-015

carboxyethyl levan

600 - 1000 (edukt)

DS ≤ 1

1 - 10 g

Datasheet

BMA-S-016

carboxymethyl levan

600 - 1000 (edukt)

DS < 1,2

1 - 10 g

Datasheet

BMA-S-017

aminofunctionalized carboxyethyl levan

600 - 1000 (edukt)

DS (CE) ≤ 1

NH2-content: variable, 40 - 600 µmol/g

1 - 10 g

Datasheet

BMA-S-018

aminofunctionalized carboxyethyl levan

600 - 1000 (edukt)

DS (CE) < 1,2

NH2-content: variable, 90 - 380 µmol/g

1 - 10 g

Datasheet

BMA-S-019

levan aldehyd

600 - 1000 (edukt)

oxidation variable

1 - 10 g

Datasheet

BMA-S-020

levan acetate

600 - 1000 (edukt)

DS ≤ 3

1 - 10 g

Datasheet

BMA-S-021

levan fatty acid ester

600 - 1000 (edukt)

DS < 1

1 - 10 g

Datasheet

BMA-S-022

sulfated levan

600 - 1000 (edukt)

DS ≤ 2

1 - 10 g

Datasheet

BMA-S-023

FITC-labeled levan

600 - 1000 (edukt)

DS < 1

1 g

Datasheet

DS = average degree of substitution

Further information on functionalized levans and polysaccharide derivatives can be found here.

Functionalized Sodium Alginates
Ref-N°SubstanceMolar mass (kDa)Degree of functionalisationBatch size 
BMA-S-024methacrylated sodium alginate100 (edukt)DS < 11 - 10 gDatasheet

DS = average degree of substitution

Further information on functionalized sodium alginates and polysaccharide derivatives can be found here.

Functionalized Chondroitin Sulfates
Ref-N°SubstanceMolar mass (kDa)Degree of functionalizationBatch size 
BMA-S-025methacrylated chondroitin sulfate (A + C)20 (edukt)DS < 11 - 10 gDatasheet
BMA-S-026acrylated chondroitin sulfate (A + C)20 (edukt)DS < 11 - 10 gDatasheet

DS = average degree of substitution

Further information on functionalized chondroitin sulfates and glycosaminoglycans can be found here.

Functionalized Hyaluronic Acids
Ref-N°SubstanceMolar mass [kDa]Degree of functionalizationBatch size 

BMA-S-027 (a - c)

hyaluronic acid with reduced molecular weight

300 - 700

80 - 150

20 - 50

not applicable

1 - 7 g

Datasheet

BMA-S-028 (a, b)

sulfated hyaluronic acid

20 - 50

50 - 2000

sHA1: DS approx. 1 - 1,4

sHA3: DS > 3

1 - 5 g

Datasheet

BMA-S-029

carboxymethyl-hyaluronic acid

12 - 20

DS ca. 0,5

1 - 5 g

Datasheet

BMA-S-030

sulfated carboxymethyl-hyaluronic acid

10 - 20

DS (CM) approx. 0,5

DS (S) ca. 3

1 - 5 g

Datasheet

BMA-S-031

amino-hyaluronic acid

13 - 20

NH2-content: variable, approx. 200 - 400 µmol/g

1 - 4 g

Datasheet

BMA-S-032

Methacrylated hyaluronic acid

30 - 1000 (edukt)

DS < 1

1 - 2 g

Datasheet

BMA-S-033

acrylated hyaluronic acid20 - 100 (edukt)DS < 1

1 - 3 g

Datasheet

BMA-S-034

methacrylated sulfated hyaluronic acid

20 - 50 (edukt)

DS (S) approx. 1 - 1,4

DS (M) < 1

1 - 2 g

Datasheet

BMA-S-035

acrylic sulfated hyaluronic acid

20 - 50 (edukt)

DS (S) approx. 1 - 1,4

DS (A) < 1

1 - 2 g

Datasheet

BMA-S-036

fluorescence-labeled hyaluronic acid

variable

DS < 1

on request

Datasheet

BMA-S-037

biotin-labeled hyaluronic acid

variable

DS < 1

on request

Datasheet

DS = average degree of substitution

Further information on functionalized hyaluronic acids and glycoyaminoglycans can be found here.

Functionalized Polyglycerols
Ref-N°SubstanceMolar mass (kDa)Degree of functionalizationBatch size 
BMA-S-038methacrylated polyglycerol (ether/ester)1 - 20 (edukt)DS < 11 - 10 g

Datasheet

BMA-S-039

methacrylated polyglycerol (urethane)1 - 20 (edukt)DS < 11 - 10 g

Datasheet

BMA-S-040

polyglycerol fatty acid ester1 - 20 (edukt)DS < 11 - 10 g

Datasheet

DS = average degree of substitution

Methacrylation Reagent
Ref-N°SubstanzMolmasseFunktionalisierungsgradBatchgröße 
BMA-S-0412-isopropenyl-4,4-dimethyl-5-oxazolone153,2 Danot applicable1 - 10 gDatasheet
Portrait von Herrn Dr. Bernd Grünler

Dr. Bernd Gruenler
Director

e-mail
Phone: +49 3641 282510

Your contacts for our synthesis offers:

Sabrina Hauspurg
Head of Department Biomaterials
e-mail
Phone: +49 3641 282512