Topic: "Functional biomaterials for controlling healing processes in bone and skin tissue – from material to clinic"
Duration: 01.07.2017 – 30.06.2021 (3rd funding period)
Project type: DFG TRR 67/3 TP Z03 TP T01
Partners: University of Leipzig Medical Center, Leipzig University, University of Dresden Medical Center, Technische Universität Dresden, Freie Universität Berlin, Helmholtz Center for Environmental Research Leipzig-Halle, Helmholtz-Zentrum Dresden-Rossendorf, INNOVENT e. V., Jena, Leibniz Institute of Polymer Research Dresden (IPF)
The demographic development in Germany and other industrial nations is causing a significant increase in the number of patients with bone defects and chronic wounds. This requires the development of innovative functional biomaterials to improve bone and skin regeneration in an aging, multimorbid population.
The structure and composition of the extracellular matrix (ECM) significantly influences cellular differentiation processes and functions and thus the healing of tissues. Therefore, TRR 67 with its 23 subprojects focusses on the development and investigation of new functional biomaterials based on artificial (a) ECM. Key functional components of these materials are glycosaminoglycan derivatives and proteoglycan analogues in combination with structural proteins or synthetic carriers.
The TRR 67 is divided into tree project areas:
Research Group A – Matrix Engineering – comprises the material science-/chemistry-oriented projects, including the associated analytics and modelling.
Research Group B – Biological profiles – bundles projects with cell biological and preclinical orientation. One focus is the systematic characterization of matrix/cell interactions in complex systems.
Research Group T – Transfer – In cooperation with an industrial partner (Mathys Orthopädie GmbH), the aim of this newly formed transfer project is to use the knowledge about the regenerative abilities of extracellular matrix components to significantly improve the osseointegration of orthopedic implants.
INNOVENT (Biomaterials) is also represented in this 3rd funding period with two projects from project area T and one central project Z in the SFB:
T1: Sulfated glycoaminoglycans as coating for endoprostheses to improve their osseointegration
Z3: Synthesis and allocation of modified glycosaminoglycans (GAG) and artificial extracellular matrices
Further information on the collaborative research center Transregio 67 can be found here.